Product Overview: KPV (Ac-KPV-NH2)

Description:

KPV is a potent tripeptide (Lysine-Proline-Valine) derived from the Alpha-Melanocyte Stimulating Hormone (α-MSH). It is highly regarded in clinical research for its powerful anti-inflammatory and antimicrobial properties. Unlike larger peptides, KPV’s small molecular structure allows for excellent cellular penetration, making it highly effective in targeting localized and systemic inflammation.

Key Specifications:

Concentration: 5 MG per vial.
Molecular Structure: Ac-Lys-Pro-Val-NH2.
Purity: ≥99% (HPLC tested).
Format: Lyophilized (Freeze-dried) powder.

Mechanism of Action (MOA)

KPV exerts its effects through multiple biological pathways to modulate the immune response:

1. Anti-Inflammatory Signaling: KPV enters the cell and interacts directly with inflammatory signaling molecules. It inhibits NF-κB, a protein complex that triggers the production of pro-inflammatory cytokines.

2. Immune Modulation: It helps balance the immune system by reducing excessive inflammatory responses without suppressing the overall immune function.

3. Antimicrobial Activity: Research indicates that KPV has natural antimicrobial effects, particularly against pathogens like Staphylococcus aureus and Candida albicans.

4. Wound Healing: It promotes the healing process by reducing the inflammatory phase of wound repair, leading to faster tissue recovery and reduced scarring.

Storage and Stability

To ensure the peptide remains bioactive and effective:

Lyophilized Powder: Store in a cool, dry place away from light. Long-term storage should be in a refrigerator (2°C to 8°C) or freezer (-20°C).
After Reconstitution: The liquid solution must be kept refrigerated at all times (2°C to 8°C).
Shelf Life: For best results in research, use the reconstituted solution within 10–14 days.
Handling Guidelines: Avoid exposing the vial to extreme heat or direct sunlight. Do not shake the vial; use a gentle swirling motion to dissolve the powder.