Ipamorelin (NNC 26-0161)
Selective Growth Hormone Secretagogue
1. Identity and Classification
Ipamorelin is a synthetic pentapeptide and a potent, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R).
It is widely recognized in clinical research as one of the cleanest and most versatile GH secretagogues. Unlike earlier generations, Ipamorelin is designed to stimulate growth hormone release without significantly impacting other pituitary hormones.
2. Mechanism of Action
Ipamorelin mimics the action of ghrelin and acts on the pituitary gland and hypothalamus to initiate a Growth Hormone (GH) pulse:
- Selective GH Release: It binds to the GHS-R receptors to trigger a pulsatile release of endogenous Growth Hormone.
- Hormonal Precision: Unlike GHRP-2 or GHRP-6, Ipamorelin does not significantly increase levels of Cortisol or Prolactin, minimizing unwanted hormonal side effects.
- Somatostatin Inhibition: It helps suppress somatostatin (the hormone that inhibits GH), further clearing the path for natural GH production.
- Ghrelin Mimetic: While it activates ghrelin receptors, it does so with less intense “hunger signaling” compared to earlier peptides in its class.
3. Potential Research Benefits
| Research Area | Targeted Effects |
|---|---|
| Body Composition | Promotes lean muscle mass accretion and supports lipolysis (fat loss) through GH-mediated pathways. |
| Bone Mineral Density | Studies indicate it may increase bone mineral content, making it a subject of interest for osteoporosis research. |
| Anti-Aging & Repair | Enhances cellular repair, skin elasticity, and improves sleep quality (deep wave sleep) associated with GH pulses. |
| Recovery & Vitality | Accelerates systemic recovery from strenuous activity and supports overall metabolic health. |
4. Storage and Stability
- Lyophilized Powder: Stable at room temperature for short periods, but should be stored at 2°C to 8°C (refrigerated) or -20°C (frozen) for long-term stability.
- After Reconstitution: Must be kept in the refrigerator (2°C to 8°C).
- Usage Window: For research integrity, the reconstituted solution should be used within 21–28 days. Avoid direct sunlight and vigorous agitation.
Disclaimer: This product is intended for laboratory research purposes only. Not for human consumption.
