Product Overview: PT-141 (Bremelanotide)

Description:

PT-141, also known as Bremelanotide, is a synthetic peptide analogue of Alpha-Melanocyte Stimulating Hormone (α-MSH). Unlike traditional treatments that target the vascular system, PT-141 is unique because it acts directly on the central nervous system by binding to melanocortin receptors. It is extensively researched for its role in treating sexual dysfunction in both men and women, as well as its effects on libido and mood.

Key Specifications:

Concentration: 10 MG per vial.
Purity: ≥99% (HPLC tested).
Molecular Formula: C50H68N14O10.
Format: Lyophilized (Freeze-dried) powder.

Mechanism of Action (MOA)

PT-141 functions as a non-selective agonist of the melanocortin receptors (primarily MC3R and MC4R):

1. Central Nervous System Activation: It bypasses the cardiovascular system and acts on the hypothalamus in the brain to trigger arousal signals.

2. Dopaminergic Interaction: By stimulating melanocortin receptors, it influences the release of dopamine, a key neurotransmitter involved in the reward and motivation pathways related to sexual desire.

3. Melanogenesis Connection: As a derivative of Melanotan II, it retains some minor affinity for receptors that regulate skin pigmentation, though its primary research focus is neurological.

Storage and Stability

To maintain the stability and effectiveness of PT-141:

Lyophilized Powder: Store in a cool, dry place. For extended preservation, refrigeration (2°C to 8°C) or freezing (-20°C) is highly recommended.
After Reconstitution: The product must be stored in the refrigerator (2°C to 8°C).
Shelf Life: For optimal research integrity, the reconstituted solution should be used within 14 days.
Handling: Protect the vial from prolonged exposure to light and heat. Avoid vigorous agitation; dissolve the powder with a gentle swirling motion.